Microplastics found in human blood for first time – “Our study is the first indication that we have polymer particles in our blood”

By Damian Carrington
24 March 2022

(The Guardian) – Microplastic pollution has been detected in human blood for the first time, with scientists finding the tiny particles in almost 80% of the people tested.

The discovery shows the particles can travel around the body and may lodge in organs. The impact on health is as yet unknown. But researchers are concerned as microplastics cause damage to human cells in the laboratory and air pollution particles are already known to enter the body and cause millions of early deaths a year.

Huge amounts of plastic waste are dumped in the environment and microplastics now contaminate the entire planet, from the summit of Mount Everest to the deepest oceans. People were already known to consume the tiny particles via food and water as well as breathing them in, and they have been found in the faeces of babies and adults.

The scientists analysed blood samples from 22 anonymous donors, all healthy adults and found plastic particles in 17. Half the samples contained PET plastic, which is commonly used in drinks bottles, while a third contained polystyrene, used for packaging food and other products. A quarter of the blood samples contained polyethylene, from which plastic carrier bags are made.

“Our study is the first indication that we have polymer particles in our blood – ​it’s a breakthrough result,” said Prof Dick Vethaak, an ecotoxicologist at Vrije Universiteit Amsterdam in the Netherlands. “But we have to extend the research and increase the sample sizes, the number of polymers assessed, etc.” Further studies by a number of groups are already under way, he said.

“It is certainly reasonable to be concerned,” Vethaak told the Guardian. “The particles are there and are transported throughout the body.” He said previous work had shown that microplastics were 10 times higher in the faeces of babies compared with adults and that babies fed with plastic bottles are swallowing millions of microplastic particles a day.

“We also know in general that babies and young children are more vulnerable to chemical and particle exposure,” he said. “That worries me a lot.”

The new research is published in the journal Environment International and adapted existing techniques to detect and analyse particles as small as 0.0007mm. Some of the blood samples contained two or three types of plastic. The team used steel syringe needles and glass tubes to avoid contamination, and tested for background levels of microplastics using blank samples.

Vethaak acknowledged that the amount and type of plastic varied considerably between the blood samples. “But this is a pioneering study,” he said, with more work now needed. He said the differences might reflect short-term exposure before the blood samples were taken, such as drinking from a plastic-lined coffee cup, or wearing a plastic face mask.

“The big question is what is happening in our body?” Vethaak said. “Are the particles retained in the body? Are they transported to certain organs, such as getting past the blood-brain barrier?” And are these levels sufficiently high to trigger disease? We urgently need to fund further research so we can find out.” [more]

Microplastics found in human blood for first time

Discovery and quantification of plastic particle pollution in human blood

ABSTRACT: Plastic particles are ubiquitous pollutants in the living environment and food chain but no study to date has reported on the internal exposure of plastic particles in human blood. This study’s goal was to develop a robust and sensitive sampling and analytical method with pyrolysis double shot – gas chromatography/mass spectrometry and apply it to measure plastic particles ≥700 nm in human whole blood from 22 healthy volunteers. Four high production volume polymers applied in plastic were identified and quantified for the first time in blood. Polyethylene terephthalate, polyethylene and polymers of styrene (a sum parameter of polystyrene, expanded polystyrene, acetonitrile butadiene styrene etc.) were the most widely encountered, followed by poly(methyl methylacrylate). Polypropylene was analysed but values were under the limits of quantification. In this study of a small set of donors, the mean of the sum quantifiable concentration of plastic particles in blood was 1.6 µg/ml, showing a first measurement of the mass concentration of the polymeric component of plastic in human blood. This pioneering human biomonitoring study demonstrated that plastic particles are bioavailable for uptake into the human bloodstream. An understanding of the exposure of these substances in humans and the associated hazard of such exposure is needed to determine whether or not plastic particle exposure is a public health risk.

Discovery and quantification of plastic particle pollution in human blood