Dead Zones in Chesapeake Bay, 2005. Wicks et al., 2007 via globalchange.gov

Climate change is likely to expand and intensify “dead zones,” areas where bottom water is depleted of dissolved oxygen because of nitrogen pollution, threatening living things. More spring runoff and warmer coastal waters will increase the seasonal reduction in oxygen resulting from excess nitrogen from agriculture. Coastal dead zones in places such as the northern Gulf of Mexico and the Chesapeake Bay are likely to increase in size and intensity as warming increases unless efforts to control runoff of agricultural fertilizers are redoubled. Greater spring runoff into East Coast estuaries and the Gulf of Mexico would flush more nitrogen into coastal waters stimulating harmful blooms of algae and the excess production of microscopic plants that settle near the seafloor and deplete oxygen supplies as they decompose. In addition, all else being equal, greater runoff reduces salinity, which when coupled with warmer surface water increases the difference in density between surface and bottom waters, thus preventing the replacement of oxygen in the deeper waters. As dissolved oxygen levels decline below a certain level, living things cannot survive. They leave the area if they can, and die if they cannot.

Global Climate Change Impacts in the United States [pdf]